Biology & Genetics · 1997
Viable Offspring Derived from Fetal and Adult Mammalian Cells
Ian Wilmut, A. E. Schnieke, J. McWhir, A. J. Kind, K. H. S. Campbell
Overview
The paper announcing Dolly the sheep, the first mammal cloned from an adult cell. It proved that the nucleus of a fully differentiated cell can be reset to support the development of a whole new animal.
Proved adult cells can be reprogrammed, transforming developmental biology.
Key findings
Methods
Somatic-cell nuclear transfer: nuclei from cultured adult sheep cells, arrested in a quiescent state, were fused into enucleated oocytes, which were then activated, cultured, and implanted into surrogate ewes.
Keywords
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