Biology & Genetics · 2001
Initial Sequencing and Analysis of the Human Genome
Eric S. Lander, et al. (International Human Genome Sequencing Consortium)
Overview
The public Human Genome Project's first analysis of the human genome sequence. It presented a draft covering most of the genome and drew early conclusions about the surprisingly small number of human genes.
Delivered the reference human genome, the foundation of modern genomics and medicine.
Key findings
Methods
Hierarchical shotgun sequencing: the genome was broken into mapped large-insert clones (BACs), each shotgun-sequenced and assembled, then stitched into chromosomes, with extensive computational annotation of genes and repeats.
Keywords
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